This article elaborates on the development of a DMAIC Manual for the restructuring of an Integrated Management System of a Brazilian company that builds real estate and corporate works, with a focus on Lean Six Sigma. The Manual was designed to lead the XYZ construction company toward a management focused on Lean Six Sigma, reducing waste and variability of its delivery processes to customers. The five DMAIC steps—define, measure, analyze improve and control—were reviewed and structured to add value to activities. The structuring and implementation of this Manual are detailed, including the management history of the company and how the Integrated Management System relates to the DMAIC.